New Florence is a borough that is located in Westmoreland County, Pennsylvania, United States.

It is also one of three communities within the county to utilise the 814 area code, alongside St. Clair and Seward.

New Florence is bordered by St. Clair Township to the east, south and west.

Across the Conemaugh River in Indiana County to the north, New Florence runs adjacent with West Wheatfield Township and has a direct connector via the 9th Street Bridge.

29.9% of all households were made up of individuals, and 16.9% had someone living alone who was sixty-five years of age or older.