Although the communities have small populations, some major political candidates campaign in the area due to New Hampshire having the first presidential primary in the nation, with George H. W. Bush, George W. Bush, Bill Clinton, Ronald Reagan, Bob Dole, John McCain, and Dick Gephardt visiting the towns.

Multiple third-party candidates, such as Andre Marrou during the 1992 presidential election, have also campaigned in the area to gain media attention.

In 1952, the town moved its voting to midnight, to facilitate greater access to the polls for railroad workers.

[5] Neil Tillotson moved to Dixville Notch in 1954, and became the town moderator and owner of The Balsams Grand Resort Hotel.

He did not like having to drive 45 minutes to the nearest polling station, but learned about midnight voting from an Associated Press reporter.

[6] Richard Nixon, in 1960, and Joe Biden, in 2020, are the only presidential candidates to win every vote in Dixville Notch in the general election.

In 1972, Incumbent President Richard Nixon and Senator Edmund Muskie won their respective primaries in Dixville Notch.

Hollings met with the town's four registered Democrats and four independents on February 19, 1984, while former Vice President Walter Mondale and Senator Gary Hart personally made phone calls to the area.

[16][17] Haig announced his campaign on March 24, 1987, in New York and then traveled to Dixville Notch later in the day after opening his headquarters in New Hampshire.

During the 2000 presidential campaign, Texas Governor George W. Bush and Senator John McCain visited Dixville Notch.

[37] Due to the COVID-19 pandemic during the general election, Hart's Location delayed its traditional midnight voting to the daylight hours.

[45] During the 2024 general election, the six Dixville Notch voters cast their ballots: three votes went to Donald Trump and three went to Kamala Harris.