New Lisbon is a town in Otsego County, New York, United States.

The town was first settled circa 1773, but most pioneers did not enter the area until after the Revolutionary War.

It is mentioned that a cultivated apple orchard was found by early settlers on the west side of the Butternut Creek near Noblesville, presumably planted by Native Americans.

Spafford's 1810 "Gazetteer" says "There are in all four or five grain-mills, seven saw-mills, a fulling-mill, and carding machine.

The inhabitants are principally farmers, and their household manufactures supply the most of their common clothing.

For a few years there was an annual fair held on the flat along the Butternut Creek at the south end of the hamlet before merging with the group holding one at Morris about 1886.

The West Branch of Otego Creek flows along the eastern town line.