[4] Over the past five years, the New Museum has exhibited artists from Argentina, Brazil, Bulgaria, Cameroon, China, Chile, Colombia, Cuba, Germany, India, Poland, Spain, South Africa, Turkey, and the United Kingdom among many other countries.

SANAA's design is chosen because it is in accord with the museum's mission—the flexibility of the building, its changeable atmosphere corresponds to the ever-changing nature of contemporary art.

Its bold decision to put a stack of white boxes in the Bowery neighborhood and its success to achieve a harmonious symbiotic relationship between the two manifest the coexistence of different dynamic energy of contemporary culture.

The neighborhood appears to be a fearless confrontation with the convention image of downtown Manhattan—an adventurous spirit that the New Museum always sees itself searching for.

The Bowery location has gallery and events space, plus a Resource Center with books and computers for access to their main web site and digital archive.

The New Museum Digital Archive is an online resource that provides accessibility to primary sources from exhibitions, publications, and programs.

[26] The museum presents the work of under-recognized artists, mounting surveys of Ana Mendieta, William Kentridge, David Wojnarowicz, Paul McCarthy and Andrea Zittel before they received widespread public recognition.

[29] Margot Norton has organized exhibitions, including one by Turner Prize-winner Laure Prouvost and the museum solo of Judith Bernstein.

Today, Rhizome's programs include events, exhibitions at the New Museum and elsewhere, an active website, and an archive of more than 2,000 new media artworks.

In 2020 the series shifted to focus on first-ever public conversations between leading figures, with Claudia Rankine and Judith Butler (2020) and Jeremy O Harris and Arthur Jafa (2021).

[37][38] Previous speakers included author Rachel Kushner (2018, in conversation with novelist Ben Lerner); explorer Erling Kagge (2017); essayist and critic Fran Lebowitz (2016, in conversation with filmmaker Martin Scorsese); critic and author Hilton Als (2015); director, screenwriter, and producer Darren Aronofsky (2014, in conversation with novelist and critic Lynne Tillman); writer, director, and producer Matthew Weiner (2013, in conversation with writer A.M. Homes); artist and architect Maya Lin (2012); chef, author, and activist Alice Waters (2011); founder of Wikipedia Jimmy Wales (2010); and choreographer Bill T. Jones (2009), whose talk inaugurated this program.

Launched in summer 2014, NEW INC provided a collaborative space for an interdisciplinary community of one hundred members to investigate new ideas and develop a sustainable practice.

NEW INC full-time members include Erica Gorochow, Anders Sandell, Lisa Park, Kevin Siwoff, Kunal Gupta, Justin Cone, Jonathan Harris, Joe Doucet, Greg Hochmuth, Luisa Pereira, Nitzan Hermon, Tristan Perich, Sougwen Chung, Philip Sierzega, Paul Soulellis, Charlie Whitney, Binta Ayofemi, Ashley Zelinskie and Emilie Baltz.

[43] IdeasCity curators included Richard Flood, Joseph Grima, V. Mitch McEwen, and Vere Van Gool.