It serves students in grades 6–12 and was described as one of the best schools in Manhattan in 2010 by the New York Post and CUNY.

Admission into the 6th grade is based on an entrance exam consisting of one page of mathematics problems and an essay.

The principal of the NYC Lab Middle School (Grades 6–8) is Megan Adams.

In May 2009, Lab collaborated with some of New York City's top restaurants for "TASTES from the Meatpacking District through Chelsea."

The festival featured a walk-around tasting of several New York City restaurants for the purpose of raising money for Lab student programs.