The route proceeds northward as a four-lane arterial, passing some businesses before entering exit 25 of the Southern State Parkway.

After that, the route bends further to the northeast, crossing over the four-lane Wantagh State Parkway as North Newbridge Road.

Just north of the local high school, NY 106 intersects with Old Country Road (CR 25) before entering downtown Hicksville.

Immediately after crossing over the Northern State, the routes enter an interchange (exit 41) of the Long Island Expressway (I-495).

After crossing back into Oyster Bay, the route becomes residential going southbound before intersecting with NY 25A (Northern Boulevard).

With this change, the divided highway becomes a two-lane local street, bending northeast near the James H. Vernon School.

The route continues north past the Upper Brookville section, changing names to Pine Hollow Road.

A short distance later, it enters the hamlet of Oyster Bay, bending northeast as a two-lane commercial/residential blend street.

Crossing Berry Hill Road, NY 106 bends northward, changing names to South Street, becoming mainly commercial.