All of NY 259 south of Curtis Road in Parma was assigned as part of the 1930 renumbering of state highways in New York.

[3] In Ogden, NY 259 takes a direct north–south alignment between the town line and the village of Spencerport.

It intersects NY 18 south of the village of Hilton in the hamlet of Parma Center, then overlaps NY 18 northward for two miles (3 km) to Hilton, where it becomes South Avenue upon entering the village, then turning left on Main Street.

The route heads north, then northeast through a hilly, rural portion of northwestern Monroe County to a junction with the Lake Ontario State Parkway just south of the shoreline.

Under the terms of the act, it took effect 90 days after it was signed into law; thus, the maintenance swap officially took place on November 26, 2007.

CR 226, meanwhile, no longer exists in any form as the remainder of the route north to the lakeshore was transferred to the town of Parma by March 2009.