It headed north, following Salt Road out of the hamlet and into a mostly rural area of northeastern Erie County.

[6][7] The origins of NY 268 date as far back as 1926, by which time the state of New York had assumed maintenance of several highways in the town of Clarence.

From here, state maintenance continued south on Salt Road to a junction with Main Street (what is now NY 5).

The first change came c. 1934 when it was realigned to head due east from Millersport on Tonawanda Creek Road.

[14] Ownership and maintenance of NY 268's former routing north of Greiner Road was transferred from the state of New York to Erie County at some point prior to 1980.

The remainder was given to Erie County on April 1, 1980, as part of a highway maintenance swap between the two levels of government.