It connects the town of Champlain to the village of Rouses Point, with both termini situated at intersections with U.S. Route 11 (US 11), approximately 5 miles (8 km) apart.

The amount of development along the route increases as it enters the village on Church Street.

[4] NY 276 serves as a truck route for traffic on US 11 as it bypasses a low-clearance railroad overpass on US 11 south of the village.

[5] The portion of modern NY 276 east of the Canadian border crossing in the town of Champlain was originally designated as part of Route 22, an unsigned legislative route, by the New York State Legislature in 1908.

[8][9] NY 348 was truncated southward to the hamlet of Chazy c. 1963, eliminating a lengthy overlap with US 9.