Passing numerous apartment buildings and residential complexes, the route continues past multiple commercial businesses before crossing into the Sedgwick neighborhood.

[3] In Eastwood, NY 290 continues northeast along James Street until reaching Shotwell Park, where it junctions with Grant Boulevard.

Continuing through Eastwood, the route expands to four lanes near the local water tower and crosses into the town of De Witt, where it junctions with NY 635 (Thompson Road) above railroad tracks.

Becoming a residential road, the route reaches a junction with the northern terminus of North Burdick Street (CR 94).

At this junction, NY 290 turns northeast as Green Lakes Road, paralleling the former Erie Canal through the town of Manlius.

At the junction with Pierson Road, the route leaves Green Lakes State Park and continues eastward away from the old canal.