The route heads southwest from this spot, utilizing a northeastward extension of Ridge Road[6] that was part of US 104 prior to the construction of the super two highway now used by NY 104.

[7] After passing 0.7 miles (1.1 km) of open farmland, the route breaks from Ridge Road and travels southeast through the Town of Butler and to the Cayuga County line.

While in Ira, the highway leaves the village of Cato and passes by Cato–Meridian Central School, located in an otherwise nondescript area of the town dominated by farmland.

It runs across another 2 miles (3.2 km) of rolling farmland before it begins to parallel the Erie Canal, here part of the Seneca River.

At this point, the open fields gradually give way to pockets of residential development as the route approaches the village of Baldwinsville.

This open stretch ends at the canalside hamlet of Cold Springs, which serves as the beginning of the Syracuse suburbs.

After passing through the community, NY 370 crosses over the conjoined Erie Canal and Seneca River and enters the town of Salina.

[6] Past John Glenn Boulevard, NY 370 passes over the New York State Thruway (Interstate 90 or I-90) near exit 38 and begins to approach the northern shore of Onondaga Lake as it enters the village of Liverpool on 2nd Street.

This section of the route also parallels the CSX Transportation-owned St. Lawrence Subdivision, which crosses the highway by way of a low, 10-foot-9-inch (3.28 m) overpass 1 mile (1.6 km) southeast of Liverpool.

[6] The parkway ends 2 miles (3.2 km) from Liverpool at the eastern tip of the lake, where the route connects to I-81 at exit 24.

[16] The portion of NY 370 west of Victory was realigned in the late 1950s to follow its modern alignment to a new terminus at US 104 (Ridge Road) southwest of Red Creek.

[8][23] On September 11, 2010, a Megabus double-decker bus hit the low 10 ft 9 in (3.28 m) railroad bridge along the Onondaga Lake Parkway killing four passengers.

An overheight warning system was set up along the Parkway in late 2011 coinciding with the banning of commercial traffic along this stretch.