[3][4] Near the Ontario County line, NY 245 turns northeast to serve the dual-county village of Rushville, located in the towns of Potter and Gorham.

NY 245 continues eastward through predominantly hilly terrain, passing through the hamlets of Gorham (where it crosses Flint Creek) and Stanley (located in the town of Seneca, centered around a former junction between the Pennsylvania and Lehigh Valley railroads adjacent to NY 245, now part of Ontario Pathways Rail Trail) before meeting NY 14A at a rural junction in the town of Seneca.

[3][5][6] In the mid-1920s, NY 52 was assigned to a series of highways connecting Dansville to Geneva by way of Wayland and Naples.

Also assigned as part of the renumbering was NY 245, which began in Pike and ended at Perry Center.

[14][15] This realignment was short-lived as NY 245 was restored to its original, direct alignment between Nunda and Dansville in the late 1950s.

[19] On January 1, 1970, the entirety of the Genesee Expressway, including its proposed routing south to Avoca and north to Rochester, was redesignated as NY 401.

NY 245 was then realigned to follow its previous at-grade routing between Dansville and Wayland.