As the third oldest dentistry school in the United States, it offers both graduate programs and clinical training in oral healthcare.

In 1957, the College moved into its present home on First Avenue, which in 1965 was named the K. B. Weissman Clinical Science Building.

[citation needed] The College of Dentistry is located on First Avenue between East 24th and 26th Streets, about 6 blocks south of the NYU School of Medicine.

These house classrooms, patient clinics, research and teaching facilities, and administrative offices, as well as a state-of-the-art Learning Commons for dentistry, dental hygiene, nursing, and engineering students and an Executive Conference Suite.

The College of Dentistry has moved its "library" into the newly opened Dental-Nursing-Biomaterials joint interprofessional building at 433 First Avenue.

In addition to traditional textbook content, students are able to view slide presentations and video streams of lab and clinical procedures and do full text searches on their materials.