Newfane is a town in Niagara County, New York, United States.

The Town of Newfane is in the north-central part of the county, north of the City of Lockport.

The first town meeting was held at the Van Horn Mansion in 1824.

In Olcott, there is a monument with a handful of names of soldiers who fought for the Union cause in the American Civil War.

In total, 252 Union soldiers came from Newfane, of whom about 55 died during service.

The town has two properties on the National Register of Historic Places: the First Baptist Church and the Van Horn Mansion.

21.9% of all households were made up of individuals, and 9.6% had someone living alone who was 65 years of age or older.