The assumed course of study at Newport High School exceeds the Smart Core curriculum developed by the Arkansas Department of Education (ADE).

Exceptional students have been recognized as National Merit Finalists and participated in Arkansas Governor's School.

For 2020–21, the Newport Greyhounds compete in the state's 3A classification within the 3A West Conference of the Arkansas Activities Association (AAA).

The Greyhounds engage in numerous interscholastic activities, including baseball, basketball (boys/girls), cross country (boys/girls), football, golf, track, soccer, softball, tennis (boys/girls), and volleyball, along with marching band, cheer, and dance.

The main building of the high school was designed by Thompson, Sanders & Ginnochio and built in 1930.