[8] The channel has publicly claimed to be centrist, but had senior staff defections in 2021 amid concerns they were being pushed by management to lean to right-wing politics in news coverage.

[14][15] The program draws partly from the broadcast and digital resources of Nexstar's television stations (including those acquired by Tribune Media, in addition to WGN America, several months prior).

[28] In May 2021, Nexstar hired Michael Corn, the senior executive producer of Good Morning America, as its news director to replace Lyons.

[33] On April 1, 2023, overnight drama series and infomercials were replaced with repeats of its evening talk and analysis shows; then on April 24, NewsNation permanently switched to a 24-hour all-news schedule on weekdays consisting of a four-hour rolling afternoon news block, NewsNation Now (replacing crime dramas in that slot), and an hour-long political news show, The Hill (a broadcast extension of the co-owned publication, replacing an hour of the early evening newscast NewsNation Rush Hour).

Syndicated scripted series acquired under the WGN America brand that remain on the schedule (such as Blue Bloods and Last Man Standing) and time-brokered programs continued to air on weekends outside of prime time.

On June 1, 2024, NewsNation expanded its all-news format to weekends, thereby completing its four-year transition into a 24/7 cable news network.

[38] On November 6, 2024, NewsNation and its partner Decision Desk HQ were the first to call the 2024 United States presidential election for Donald Trump.

[39] In 2023, NewsNation gained significant attention for its focus on UFO issues,[40][41] to which it devotes more coverage than most other cable news networks.

"[41] NewsNation was forced to issue corrections after incorrectly claiming that The Intercept had obtained leaked information regarding Grusch's mental health.

[43][44] On January 12, 2024, the network hosted a forum featuring three challengers in the Democratic primaries (Dean Phillips, Marianne Williamson, and Cenk Uygur).

[45] NewsNation is available on most multichannel television providers (including cable, satellite, IPTV and fiber-optic-based services) within the United States.

Moreover, some multichannel providers in various markets where Tribune Broadcasting had owned a television station prior to the closure of the group's purchase by Nexstar do not carry NewsNation.