The company publishes 194 news weeklies in health and other fields, which are distributed to subscribers and partners including LexisNexis, Factiva, The Wall Street Journal Professional Edition, Thomson Reuters, ProQuest, and Cengage Learning.

[3] In the early 2000s, the firm added the imprint VerticalNews to publish news weeklies in non-health fields.

[1][5] In 2015, NewsRx launched the BUTTER platform, a knowledge discovery engine that delivers its content to academics, researchers, and professionals.

[2] The idea for the first newsletter originated at an international conference on AIDS sponsored by the Centers for Disease Control and Prevention (CDC).

[1] Articles included summaries of peer-reviewed research, conference reports, news releases, and compilations from other health and medical organizations.

[14] In 1999, the firm also adopted Artificial Intelligence Journalist (AIJ) which uses robotics, machine learning, algorithms, logic, and automated reasoning to provide computer-assisted reporting and data-driven journalism.

[4] The firm also adopted site licenses, including the ability for users to download reports showing the types of information used in a given organization—information previously restricted to the NewsRx staff.

[3][19] At the company's beginnings, Newsweek magazine commented that AIDS Weekly, as a non-government entity, should not be reporting on topics that included policy, research, and statistics that some[who?]

[20] The firm was also involved with The New York Times in controversial breaking news about AIDS studies that had purposely been tampered with at the CDC.

[21] In 2011, the firm partnered with ScholarlyMedia's ScholarlyEditions imprint, publishing 4,000 reference books, which replaced the EncyK line.