[1] Her parents divorced and her mother, Nguyễn Thi Phuong was a secondary school teacher in Thạnh Phú District in Bến Tre Province.

[4] In April 2018, Phương Khánh was second runner-up at Miss Sea Vietnam Global pageant, winning a cash prize of VND 200 million (USD 8,770).

[8] She represented Vietnam and won the Miss Earth 2018 pageant held on November 3, 2018, at Mall of Asia Arena in Pasay, Metro Manila, Philippines.

[13] Phương Khánh returned to Vietnam a week after winning Miss Earth 2018 and received a grand welcome by her family, friends, and supporters at the Tan Son Nhat International Airport.

[18] She appeared on the cover of Harper's Bazaar magazine in its December 2018 Vietnam edition, and was interviewed about her life and success in the Miss Earth pageant.

[27][28] Phương Khánh launched a project with the Southern Customs Office Department in Vietnam on April 10, 2019, and awarded 20 scholarships worth 1 million VND to 20 students with financial difficulties, awarded a youth project of a sterile drinking water supply system for Nhon Chau High School and 2 sterilized drinking water machines for Thon Tay Kindergarten, tree planting activities and marine environment cleaning in Nhon Chau island in Quy Nhơn, Bình Định Province.

[31] She attended the Vietnam International Fashion Week 2019 in Ho Chi Minh City in which she walked at the opening ceremony on April 11, 2019, and wore the creation of Chung Thanh Phong.

[34] She was also featured in May 2019 in the "Proud Vietnam" project, a photo collection book to honor Vietnamese celebrities who won international pageant titles or global recognitions.

[37] Along with Miss Earth Air 2018, the Austrian, Melanie Mader, she attended the World Environment Day conference followed by a tree planting event on June 4, 2019, in Réunion Island.

[54] She also witnessed the signing of a cooperation agreement between the Japanese Language Association for Non-Kanji Using Learners (JLAN) with Dai Nam University to train and give opportunities for Vietnamese to study and work in Japan.

[51] She was the cover of The Lifestyle Journalist Magazine based in India in the July 2019 edition with an exclusive interview regarding her feat in the Miss Earth pageant and her future plans.

[66][67][68] In addition to the pageant crowning, she also performed social work activities, tree planting, and environmental protection and community awareness campaign and received an "Award of Excellence" from The Earth Saviors Foundation based in India.

[73][74][75] During her reign as Miss Earth, she had traveled to the Philippines, Vietnam, Réunion Island, Singapore, United States, Japan, Colombia, India, Malaysia to fulfill her duties.