[3] On January 1, 1972, Nguyễn Sinh Hùng was employed as an officer at the Central Bank for the Construction of the Ministry of Finance.

Nguyễn Sinh Hùng joined the Communist Party of Vietnam on May 26, 1977, and was granted formal membership on May 26, 1978.

On June 28, 2006, Nguyễn Sinh Hùng was approved by the National Assembly as the 1st Deputy Prime Minister, following the proposal of Prime Minister Nguyễn Tấn Dũng to undertake joint work in the government's work management system.

Deputy Prime Minister Nguyễn Sinh Hùng also served as Head of the Restructuring Steering Committee of Vietnam Shipbuilding Industry Corporation (Vinashin) after the Vinashin case was wrongly dealt a debt of $5 billion and unable to pay.

Nguyễn Thị Kim Ngân replaced his position as the Chairman of the National Assembly on 31 March 2016.