[5] Thu Nhi made her professional debut on 3 October 2015, scoring a six-roundpoints victory against Bo Ra Kim at the Nguyen Du Gymnasium in Ho Chi Minh City, Vietnam.
[8] Thu Nhi was booked to face Kanyarat Yoohanngoh for the vacant WBO Asia Pacific minimumweight title on 29 February 2020, at the Felix Hotel Casino in Bavet, Cambodia.
The fight was scheduled for the undercard of the Olimjon Nazarov and Michael Mendoza WBO Oriental flyweight title bout, which took place on 23 October 2021 at the Wadong Gymnasium in Ansan, South Korea.
[11] Thu Nhi faced the IBF mini flyweight champion Yokasta Valle in a title unification bout on 8 September 2022.
The bout headlined a DAZN broadcast card, which took place at the Ciudad Deportiva Heiner Ugalde in San José, Costa Rica.