[citation needed] Duy Nhất discovered Muay Thai in 2007 when he left to study in Ho Chi Minh City.

[1] Nguyễn Trần Duy Nhất made his first Muay Thai appearance at the 2009 Asian Martial Arts Games, competing in the men's featherweight division (54–57 kg).

[3] On July 2, 2013, Nguyễn Trần Duy Nhất would defeat Daniiar Kashkaraev of Kyrgyzstan, 5–0, to win the gold medal in the men's featherweight category in Muay Thai at the 2013 Asian Indoor and Martial Arts Games.

[5] On September 23, 2017, Nguyễn Trần Duy Nhất fought at the inaugural Asia Fighting Championship event, where he defeated Huang Guang Wan by second-round technical knockout.

He won by second-round KO[18] On October 22, 2022, Duy Nhất faced Phan Huy Hoàng in the 60kg tournament semi-finals at Lion Championship 2.

[22] On February 22, 2019, Duy Nhất made his lethwei debut at WLC 7: Mighty Warriors,[23] where he defeated Pich Mtes Khmang by knockout at 2:13 of the first round.

[24] On August 2, 2019, he returned to World Lethwei Championship at WLC 9: King of Nine Limbs, where he defeated Izat Zaki by unanimous decision.