The 300 km long Nhamundá River originates in the plateau Serra do Jatapu near the division of the Brazilian States of Roraima, Amazonas and Pará, and from there it flows in a southeastern direction, forming the natural division between Amazonas and Pará.

It then crosses the Nhamundá-Mapuera Reserve (EG033) before joining the Trombetas River near the city of Oriximiná.

The three towns on the river's lower reaches (Terra Santa, Nhamundá, and Faro) are accessible only by boat.

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