The Nhandú River (Portuguese: Rio Nhandú) is a river in the states of Pará and Mato Grosso, Brazil.

The Nhandú River flows southwest from Pará into Mato Grosso, where it is a right tributary of the Teles Pires.

It defines the eastern boundary of the 184,900 hectares (457,000 acres) Cristalino State Park, created in 2000.

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