[3] In October 2016, Billboard magazine confirmed that Lopez is working on her second Spanish album, which was originally set to be released in 2017 through Sony Music Latin.

[7] The single's cover art features Lopez posing in front of a sea, clothed in a 1960s-inspired yellow gown custom designed by Michael Costello.

[8] The track sees Lopez and Gente de Zona "pronounce their love for one another over a joyful production",[10] which features a reggaeton beat and horn section.

"[2] MTV UK labelled it a "future smash hit" and wrote: "Here's hoping that 'Ni Tú Ni Yo' follows the international success of other Spanish bangers like 'Bailando' and 'Despacito'.

[10] Brooke Metz of USA Today said: "The song, with its fast pace, swinging trumpets and all-Spanish lyrics, creates the perfect soundtrack for beach days and summer nights.

[18][19] Lopez and Gente de Zona officially premiered the song during her performance at Macy's July 4 Fireworks Spectacular, which aired the same day.

[24] Lopez shared an image from the set of the video shoot on June 13, in which she and Gente de Zona are featured wearing Caribbean-styled outfits.

It features several product placements and cameos from Anthony, Mexican actor Khotan Fernández, and actor/Sprint "Test Man" Paul Marcarelli.

[26] According to Billboard, set in Miami, the clip "tells the story of Lopez falling in love with a photographer she met through her manager (played by ex-husband Marc Anthony), while also enjoying life in a tropical paradise.