Peeples is known for playing Nicole Chapman on the TV series Fame; Pam Fields on the drama Pretty Little Liars; Karen Taylor Winters on The Young and the Restless; Sydney Cooke on Walker, Texas Ranger; and as Grace's mom, Susan, on The Fosters.

[citation needed] She operates an internet based organization called Elements of Life, which promotes fitness, inspiration, healthy lifestyle changes and emotional well-being.

[5] She made a music video in 1986 for "All You Can Dream", directed by Alan Bloom and conceptualized by Keith Williams, for the purposes of promoting the values of UCLA.

On February 4, 2009, Peeples presented Debbie Allen with a Lifetime Achievement Award at The Carnival: Choreographer's Ball 10th anniversary show.

[6] Notably, Peeples portrayed performing arts student Nicole Chapman on the hit TV series Fame.