Niccolò Caetani di Sermoneta (1526–1585) was an Italian Roman Catholic cardinal and bishop.

[1] At the age of 10, Pope Paul III made him a cardinal deacon in pectore in the consistory of 22 December 1536.

[1] His elevation to the cardinalate was published in the consistory of 13 March 1538; he received the red hat and the deaconry of San Nicola in Carcere on 16 April 1538.

[1] He participated in the papal conclave of 1565-66 that elected Pope Pius V.[1] In 1570, he became cardinal protector of the Kingdom of Scotland.

[1] His body was transferred to Loreto and he is buried there in the Basilica della Santa Casa.