He was a close associate of Sicilian military man and diplomat Ruggero Paruta.
[citation needed] He was in good terms with famous Italian literary author Antonio Beccadelli.
[citation needed] It is most likely, that both, Speziale and Beccadelli attended the wedding in 1420, of Infante John of Aragon to the widowed Navarrese Princess Blanche I of Navarre.
[citation needed] Aragonese power, centered on Sicilian-Spanish families, such as Ávalos or Davalos, Moncada, or Montcada, Cabrera, Cardona, Chiaramonte, Folch de Cardona, Aragón or Aragona, Requesens, Ximenez de Urrea, Luna, Centelles, Moncayo Pignatelli, Platamone, Caracciolo, Tagliacozzo, Corella, Paternò, and Ventimiglia.
Contemporary humanists and academicians were likely indebted to Speciale, such as Iovianus Pontanus and Neapolitan Jacopo Sannazaro, who influenced also Spanish poetry of the early Renaissance.