[2] In June 1423 in Aversa, on the occasion of Louis III of Anjou's adoption by Queen Joanna II as her heir, Acciapacci delivered a public speech in his honour, Vere filius Dei est iste.
[8] Acciapacci helped arrange the alliance of Pope Eugene, the Republic of Genoa and Francesco Sforza to support René's claim to the Neapolitan throne.
In November 1441, as King Alfonso V of Aragon gradually surrounded Naples, Acciapacci wrote to Sforza for reinforcements.
[2] While pursuing detente with Alfonso, Pope Eugene declared Acciapacci persona non grata in Rome at the king's urging.
[11] On account of the cardinal's closeness to Sforza, with whom the pope was in conflict over the March of Ancona, he was not recalled from exile during Eugene's lifetime.
[2] According to Piccolomini, he was widely regarded as a leading candidate: The cardinal of Capua, when he heard Eugenius had died, came to Rome and was received with great favor by people and clergy.
[14]He voted for the successful candidate, Nicholas V. He was entrusted with overseeing the canonization process of Bernardino da Siena, but died before carrying this out on 3 April.