His grandfather Nicolo is referred to as an artist, his father Pietro di Niccolo mentioned in the contracts with the painters of his generation—Donato and Katarina.
In recent years, more and more approved by the view that the most famous Venetian painter of the second half of the 14th century Lorenzo Veneziano was the brother of the father of the artist - Pietro di Niccolo.
If this theory is correct, then Nicolo di Pietro, therefore, was the nephew of Lorenzo.
As in the work of Lorenzo and Pietro pronounced tendency to adapt Gothic painting, the researchers believe that this family was the main promoter of the North, the Gothic influence in Venetian art.
In this regard, some researchers believe that Niccolo di Pietro could be a disciple of Giovanni da Bologna, as in the will of the latter from 23 to 24 October 1389 referred to a «Nicolao suo disipulo» ("his student Nicole").