His son, Piero di Niccolò Lamberti (1393–1435), was also a sculptor, and the two are notable for exporting the Tuscan style of sculpture to Venice, where they were active in the late 1410s and 1420s.
In 1401 he was one of the artists who participated in the contest that was held to design the North doors of the Florence Baptistery, won by Lorenzo Ghiberti.
In 1408 he was chosen as one of three sculptors to create one of the seated Evangelists (Saint Mark) for Florence Cathedral.
In Venice, his significant role in the sculpture of the upper storey of the Saint Mark's Basilica façade is notable.
Lamberti is also responsible for two series of capitals at Orsanmichele, one on the right side of the arcade of the eastern façade and one on the left side of the arcade of the southern façade.