The eldest son of Sir Thomas Le Strange, he succeeded his father in 1545 and was knighted in 1547.
His mother was Anne, a daughter of Nicholas Vaux, 1st Baron Vaux of Harrowden and half-sister of Sir Thomas Parr, making Nicholas a cousin to Catherine Parr, the sixth queen of King Henry VIII.
[1] On 15 September 1549 he wrote to William Cecil, the king's attorney, denying any sympathy with Kett's rebellion.
[2] In March 1552, during the reign of Edward VI, le Strange succeeded Sir Walter Buckler as chamberlain to Princess Elizabeth's household at Hatfield, Hertfordshire.
(His brother, Richard Lestrange, also sat as an MP for boroughs under the Duke of Norfolk's influence in 1559 and 1563.)