He has had an extensive career in film and television since he graduated in 1984, but is best known as a stage actor, having appeared in productions in Australia, London, New York and Edinburgh.

[2] He has had guest roles in most Australian series including Water Rats, Tough Nuts: Australia's Hardest Criminals, The Surgeon and Tricky Business.

Papademetriou has also directed a number of successful productions including And Miss Reardon Drinks A Little, Lady Windermere's Fan, Anna in the Tropics.

In 2014 he created a new role in the world premiere of Aiden Fennessey's new play for two actors called The Way Things Work for the Tamarama Rock Surfers and directed by Leland Keen.

In February 2017, he appeared as Howard in the Australian premiere of The Mystery Of Love & Sex by Bathsheba Doran at Sydney's Eternity Theatre.