The artists he has collaborated with and written for include Jason Aldean, the Rolling Stones, Avril Lavigne, Hootie & the Blowfish, Kenny Chesney, Carly Simon, Taylor Swift, Garbage and Everclear.

During his 5 years at Rondor, Brophy engineered alongside veteran producers Lou Adler (the Mamas & the Papas, Carole King), Richard Perry (Harry Nilsson, Barbra Streisand, Art Garfunkel), Bones Howe (Elvis Presley, Tom Waits, the Fifth Dimension) and contemporary producers Greg Wells (Katy Perry, Adele, One Republic), Jay Joyce (Wallflowers, Patty Griffin, Eric Church) as well as writers and artists Michael Masser, Gerry Goffin, Olivia Newton-John, Everclear, and Garbage.

While at Rondor, Brophy was signed to EMI Music Publishing and had international success with records by Trine Rein, Momoko, Jill Johnson, and Coco Lee as well as film and TV placements including ABC's "Wasteland" (theme song),[citation needed]> Eddie Murphy's “Pluto Nash”(movie trailer) and a song on the motion picture soundtrack for "The Wedding Planner".

In Nashville Nick has written, produced, engineered and mixed albums and singles with; Vassar, Taylor Swift,[6] Jennifer Hanson, Hootie & the Blowfish,[7] the JaneDear Girls, Kip Moore, Big & Rich, Jimmy Fallon and many others.

Nick's work as a mixer has earned him several number 1's as well as Fallon's “Blow Your Pants Off” winning a Grammy for best comedy album.

Their songs have been heard on ABC, NBC, FOX, CMT, MTV, VH1, PBS, HGTV, The CW, Freeform, Netflix, Discovery Channel, Cox Communications, Hulu, Paramount+, TV Land, Showtime and in films and movie trailers for Sony, Columbia, Disney and Warner Bros Pictures.

Notable placements have been Grey's Anatomy, The Bold Type, Younger, Selling Sunset, Station 19, Songland, Emily In Paris, Ghosted, A Million Little Things, My Kitchen Rules, Deadliest Catch, America's Got Talent, America's Funniest Home Videos, Astrid & Raphaëlle and Restored By The Fords, as well as in national and international advertising campaigns and promo spots for Xbox, Target,[11] Ford,[12] Coors Light and AdventHealth.