A member of six teams, he achieved his greatest success with the Philadelphia Eagles, leading the franchise to their first Super Bowl title.

He led the Eagles throughout their playoff run, which culminated with a victory in Super Bowl LII and him earning the game's MVP award.

Foles opted out of his contract with the Eagles to join the Jacksonville Jaguars in 2019, but suffered an injury during the season opener that caused him to miss most of the year.

[4][5][6] Foles also excelled at basketball, where he started three years, twice received team MVP honors,[6] and was recruited by Georgetown, Baylor, and Texas.

He also played high school football with Justin Tucker, kicker for the Baltimore Ravens, and Kyle Adams, a former tight end for the Tampa Bay Buccaneers and Chicago Bears.

[10][11] After quarterback Willie Tuitama graduated, Foles competed with expected successor Matt Scott, who got the nod after spring practice because the coaches believed he could run effectively as well as pass.

[23] The following week against the division rival Dallas Cowboys, after Vick left the game in the second quarter with concussion symptoms, Foles made his NFL debut.

[26] On Monday, December 3, 2012, Eagles coach Andy Reid announced that Foles would start for the rest of the year, regardless of when Vick returned from a concussion.

With two seconds remaining on the clock and Philadelphia down 21–16 at the Bucs' one-yard line, Foles threw a 1-yard pass to Jeremy Maclin for the game-winning touchdown as time expired.

[30] Going into training camp, new head coach Chip Kelly announced that Foles would compete with Vick and newly drafted rookie Matt Barkley for the Eagles starting quarterback job in the 2013 season.

[46] For the seventh time this season, Foles's passer rating eclipsed 100, as he completed 21 of 34 attempted passes for a total of 237 yards, with 3 touchdowns and no interceptions.

[50] Foles helped lead the Eagles to their first NFC East division title in three years by beating the Cowboys in the regular season finale.

He was also aided by rookie receiver Jordan Matthews, second year tight end Zach Ertz, and veteran running back Darren Sproles.

[58] Foles fought off the slow starts of games past, a strong Washington defensive front seven, and a brutal blindside hit from Washington defensive lineman Chris Baker which resulted in a major brawl between both teams and causing Eagles left tackle Jason Peters, the strongest player in their line, and Baker to be ejected from the game.

In Week 8, Foles set a franchise record for most completions in a game with 36 and threw a career-high 62 times in a close loss to the Arizona Cardinals, finishing with 411 passing yards and 2 touchdowns.

In overtime, Foles threw a 22-yard pass to wide receiver Stedman Bailey, which set up the Rams' game-winning field goal over the defending NFC Champions.

[70] After that game, Foles' problems with turnovers from 2014 started to show, as he completed 11 passes out of 30 for 141 yards, 1 touchdown, and a career-high 4 interceptions against the Green Bay Packers.

[80] On March 13, 2017, Foles signed a two-year contract to return to the Philadelphia Eagles to back up 2016 first-round pick Carson Wentz.

[86] On January 13, 2018, the Eagles defeated the Atlanta Falcons 15–10 in the NFC Divisional playoff game, with Foles completing 23 of 30 passes for 246 yards.

[97] Foles led the Eagles to a 1–1 record through two games, with 1 touchdown pass, 1 interception, and a 78.9 passer rating, before Wentz returned as the starter for Week 3.

[98][99] On December 12, 2018, it was announced that Wentz would probably sit out due to a back injury in the Week 15 game against the Los Angeles Rams, thus giving Foles his third start of the season.

[103] On December 30, in a Week 17 game with the Washington Redskins, Foles tied the NFL record for consecutive pass completions with 25 in a row,[104] while the Eagles clinched a playoff berth.

[105] In the Wild Card playoff game against the Chicago Bears at Soldier Field, Foles led the Eagles on a game-winning touchdown drive that culminated with a pass to Golden Tate with 56 seconds left in the game as the Eagles won 16–15 and advanced to play the top-seeded New Orleans Saints in the Divisional Round.

Days after the game, head coach Doug Marrone announced that Foles would be benched and Minshew would retake the starting job.

[121] After not seeing action in the first two games of the 2020 season, Foles replaced a struggling Trubisky in the third quarter against the Atlanta Falcons as the Bears trailed by 16 points.

[123] In Week 5 against the Tampa Bay Buccaneers on Thursday Night Football, Foles threw for 243 yards, one touchdown, and one interception during the 20–19 win.

[125] In Week 10 against the Minnesota Vikings on Monday Night Football, Foles threw for 106 yards and an interception before suffering a hip injury that required him to be carted off the field after being slammed to the turf late in the fourth quarter.

[126] Once again the backup, Foles did not see action until Week 16 in Jacksonville when he took over during garbage time in the fourth quarter; he mostly handed off the ball and his lone pass attempt was incomplete as the Bears defeated his former team 41–17.

[128] After being a healthy scratch throughout most of the 2021 season, Foles made his first start in Week 16 against the Seattle Seahawks due to Justin Fields and Andy Dalton dealing with injuries.

[135] On September 16, 2024, he signed a ceremonial one-day contract to retire with the Philadelphia Eagles, and served as the team's honorary captain later that day for their 2024 season home opener against the Atlanta Falcons.