[1][2] After interning at Governor George Pataki's office and running a congressional campaign for Brett Sommer in 2000, Langworthy became a staffer for Congressman Thomas M. Reynolds.

[1][4][better source needed] Erie County Republican Committee Chair James P. Domagalski resigned his chairmanship in 2010 to run for the New York State Senate.

Langworthy unanimously won a special election for the chairship, becoming the youngest chair of either political party in Erie County's history.

[7] Paladino's primary upset, together with the Republicans' successful effort to take control of the Erie County legislature, led Buffalo News chief political columnist Bob McCarthy to call Langworthy the "GOP's Young Elder".

[11] In September 2019, it was announced that Langworthy would be succeeded as Erie County chair by Boston, New York Republican chair Karl J. Simmeth Jr.[12] In 2018, Langworthy began campaigning for the chairship of the New York State Republican Committee against incumbent state chairman Ed Cox.

[17] In June 2022, U.S. Representative Chris Jacobs, who was running in New York's 23rd congressional district, announced that he would withdraw from the race and not seek reelection.

Langworthy subsequently announced his candidacy for the seat, which represents portions of the Buffalo suburbs and most of the Southern Tier.