He played club level rugby league (RL) for the South Sydney Rabbitohs, the St. George Dragons, the Hunter Mariners, the Cronulla-Sutherland Sharks and the Bradford Bulls, usually as a wing, but also as a centre, and representative level rugby union (RU) for Italy, and at club level for Rugby Roma Olimpic, as a wing or centre.
Nick Zisti began his professional career playing for the South Sydney Rabbitohs where he made 6 appearances off the bench between 1991 and 1993, scoring no points.
[4] Following the club's demise, he moved to the Cronulla-Sutherland Sharks where he played nine games scoring four tries in the season of 1998.
[3] After spending all of his career in Australia he decided to move to England to play in the Super League club the Bradford Bulls.
In December 2001, because of Rugby Roma's financial problems, he asked to be let free and flew back to Australia.