Nicky Guadagni (born August 1, 1952) is a Canadian actress who has worked on stage, radio, film and television.

Originally from Montreal, Nicky Guadagni majored in drama at Dawson College and went on to train at the Royal Academy of Dramatic Art in London.

Her first role after graduation was playing Miranda, with Paul Scofield as Prospero, in a production of The Tempest in the West End of London.

In 2002 Guadagni made her playwriting debut with In the Wings, adapted from the 1998 novel by Carole Corbeil, which she performed at Toronto's Theatre Passe Muraille.

[5] In 2019, she played the demented matriarch Helene Le Domas in the horror film Ready or Not.