[2] Musoke began his MMA career as an amateur in 2005 taking on Jasper Gunnarsson in a losing effort via split decision.
Musoke suffered his first professional loss at the hands of future BAMMA and UFC fighter Danny Mitchell, via armbar in the second round.
On June 18, 2011, he took part in a four-man tournament held by On Top Promotions where the winner would leave as the OTP Welterweight champion.
Musoke took his place and defeated another fellow future UFC fighter in Stevie Ray by submission due to a rear naked choke at the end of the first round to become the OTP Welterweight champion.
[17] However, Sadollah was pulled from the pairing with Musoke in favor of a bout with Yoshihiro Akiyama on September 20, 2014, at UFC Fight Night 52.
[22] In a back-and-forth fight, he lost by knockout in the last minute of the third round when Veličković connected with a right hook to the temple, causing Musoke to become wobbled and fall to the ground .
[23] On September 12, 2018 - over a year after his last fight in the UFC - it was announced that Musoke had signed a contract with his native Superior Challenge and will be moving up to middleweight.