Nicolas Brignoni (born 3 September 1976 in Montevideo)[1] is a former Uruguayan rugby union player, of Swiss origin.
Brignoni played in Europe for L'Aquila Rugby, from Italy, from 2002/2003 to 2005/2006, and US Montauban, from France, in 2006/2007.
He holds 47 caps with 9 tries scored, 45 points in aggregate, for Uruguay national rugby union team.
His first game was at 8 June 1998 in a 72-5 loss to Argentina XV, in Buenos Aires, in a tour.
He had his last cap at the 21-21 draw with Romania, at 23 November 2010, for the 2011 Rugby World Cup qualification repechage, in Montevideo.