Nicolás Fasolino (January 3, 1887 – August 13, 1969) was an Argentine Cardinal of the Roman Catholic Church.

From 1913 to 1922, Fasolino successively served as a professor at the Center of Religious Studies in Buenos Aires, Vice-Chancellor of the archdiocese, and general visitor to the Young Workers Association of Argentina.

Fasolino was promoted to the rank of Archbishop upon the elevation of Santa Fe to a metropolitan archdiocese on April 20, 1934.

He later attended the Second Vatican Council from 1962 to 1965, and was created Cardinal Priest of Beata Maria Vergine Addolorata a piazza Buenos Aires by Pope Paul VI in the consistory of August 13, 1969.

Cardinal Fasolino died in Santa Fe, at the age of 82, having served as the Ordinary of that city for thirty-six years.