Nicolás Mazzarino (born October 21, 1975) is a former Uruguayan professional basketball player, and current assistant coach for Club Biguá de Villa Biarritz of the Liga Uruguaya de Básquetbol.

Mazzarino began his professional career in the Uruguayan club Hebraica y Macabi in 1991.

In this club, Mazzarino won the Uruguayan Federal Championship title in 1994.

In 2001, he moved to the Italian League, to play in Viola Reggio Calabria, where he became the team's captain and best scorer in the 2004–05 season.

Mazzarino played with the senior Uruguayan national team from 1997 to 2014.