[4] Nicolás was a nephew of Father Jacinto Zamora, one of the three priests collectively called Gomburza executed after being implicated to the 1872 Cavite mutiny.

[1] Zamora then took up law as his master's degree prerequisite for priesthood at the University of Santo Tomas, but his schooling was interrupted by the outbreak of the Philippine Revolution in 1896.

[5] He served as a Teniente Mayor (Chief Lieutenant) in the Philippine Revolutionary Army under the command of General Gregorio del Pilar.

[8] In the First District Conference held on 20–23 August 1900, Zamora reported that his evangelistic work had reached seven places, with eight weekly services, 220 probationary members, seven Filipino workers, seven baptisms, and 38 marriages.

Since the Catholic priest was unable to suggest a topic for discussion, Zamora chose sainthood and the futility of prayers to the saints.

The following Sunday, with more than 2,000 people eager to witness the discussion, Zamora brought his Bibles (which included the translation of Father Scio Torres Amat, the Latin Vulgate, the Hebrew, and the Greek versions) to Tangag.

Tangag was quick to retreat to the convent, prompting the crowd to shout in unison, "¡Viva Cristo y su Evangelio!"

[11] In recognition of these efforts, Bishop Frank W. Warne forwarded the ordination of Zamora as an elder of the Methodist Episcopal Church.

Their primary purpose was to accelerate the pace of evangelism and initiate methods that would make Filipino evangelists be at par with their American counterparts.

[19] On 20 February 1909, Nicolás Zamora met with the society members at the house of Moises Buzon in Tondo, wherein they agreed to secede from the Methodist Church.

[20] On 28 February 1909, Zamora delivered a sermon before calling to the members to secede from the Methodist Episcopal Church.

The Iglesia Evangelica Metodista en las Islas Filipinas was founded, making it the first indigenous Protestant church in the Philippines.

[21] Seeing the developments among Protestant lines, Bishop Aglipay offered Zamora a high position in the Philippine Independent Church, which had more than two million members by the time.

Zamora turned down the offer, which led to Isabelo de los Reyes to describe him as: A man who was not swayed by the attraction of pomposity, even of honor, who did not fall to the temptation of power, who dedicated his life in order to gain the full freedom of Philippine Methodism.Evident lack of evangelists, preachers, financial resources and physical facilities did not hinder Zamora to carry on the preaching of the Gospel.

In the First Ministerial Conference of the new Filipino Church in 1910, Zamora was elected as the first General Superintendent of Iglesia Evangelica Metodista en las Islas Filipinas.

Persevere in your responsibilities as loyal Christians and servants of the Lord Jesus, for a man’s honor lies in his fulfilment of his responsibilities.Finally, on 14 September 1914, Zamora died at the age of 39.

[27] On 14 September 2014, Zamora's death centennial was commemorated by the Iglesia Evangelica Metodista en las Islas Filipinas.