Born in Ruvo di Puglia, Girasoli was ordained to the priesthood on 15 June 1980 by Pope John Paul II.

To prepare for a diplomatic career, he entered the Pontifical Ecclesiastical Academy in 1981.

[2] On 24 January 2006, Pope Benedict XVI appointed him nuncio to Zambia and Malawi, and titular archbishop of Egnazia Appula.

[2] He received his episcopal consecration on 11 March from Cardinal Angelo Sodano, with Archbishop Robert Sarah, and Bishop Luigi Martella as co-consecrators.

[5] In May 2018, he was mentioned as a possible candidate to fill the position of Substitute for General Affairs in the Secretariat of State because he was thought to be "very close to Pope Francis and agreeable to Cardinal Pietro Parolin", the Secretary of State.