Prince Nicolae Crețulescu (Romanian pronunciation: [nikoˈla.e kret͡suˈlesku], surname also spelled Kretzulescu; 1 March 1812 – 26 June 1900) was a Prince Wallachian, later Romanian politician and physician.

Born in Bucharest, he studied medicine in Paris, having Gustave Flaubert as a colleague.

As a physician, his notable work was the translation of Jean Cruveilhier's manual of anatomy.

A member of the Liberal faction, Crețulescu first became prime minister after the assassination of Barbu Catargiu, under ruler Alexandru Ioan Cuza.

Additionally, he laid the groundwork for further laws secularizing the property of monasteries.