[4] He made his Bundesliga debut in a 3–6 defeat to Borussia Mönchengladbach on 29 August 2010 being introduced as a substitute after 63 minutes.

In September, the club announced to have had exercised a purchase option, making the deal permanent with Jørgensen signing a contract until 2016.

[7][8] In his first season at the club he became the Eredivisie's top scorer with 21 goals, helping Feyenoord to win their first title since 1999.

[9] On 22 April 2018, he scored the opening goal as Feyenoord won the 2017–18 KNVB Cup final 3–0 against AZ Alkmaar.

[14] On 14 November 2015, he scored his first international goal for Denmark national football team in the UEFA Euro 2016 qualifying Playoffs against Sweden.