From 2016 to 2021, she had a recurring role as Becca Dorsay, ex-wife of one of the series leads on the Canadian-produced crime drama Private Eyes.

[5] De Boer's television debut was an uncredited role in Freddy the Freeloader's Christmas Dinner, which starred Red Skelton and Vincent Price.

Her first major television work was in the CBC series 9B,[2] followed by a recurring role on the Canadian sketch comedy show The Kids in the Hall as Laura, girlfriend of Bobby Terrance (Bruce McCulloch).

She starred in the short-lived 1997 SyFy Channel series Deepwater Black[6] (also known as Mission Genesis) as Yuna.

De Boer's other roles have included Ezri Dax on Star Trek: Deep Space Nine's final season (1998–1999), and Sarah Bannerman on the series The Dead Zone (2002–2007).