She is best known her role of Jennie Bradbury in the critically acclaimed FOX television series Pasadena, which was directed by Diane Keaton and created by Mike White.
Paggi continued to appear in guest roles on television series such as Glory Days, Fastlane, Judging Amy, CSI: Miami and the CBS pilot Expert Witness.
Her other television credits include guest appearances in Quintuplets, Jake in Progress, CSI: Crime Scene Investigation, for which she appeared in 2002 and again in 2008, Mad Love and 90210, as well as the television films Campus Confidential and Undercover Bridesmaid.
In 2011, she starred in Girls Talk, a play written by Roger Kumble, alongside Brooke Shields and Constance Zimmer, and was nominated for an Ovation Award.
After giving birth to her first daughter, Nicole stepped away from acting to focus on her family and being a mother.