Nicole Thyssen (Dutch: Thijssen;[1][2] born 5 June 1988) is a Dutch retired tennis player.

In her career, Thyssen won five singles titles and 18 doubles titles on the ITF Women's Circuit.

She reached her best singles ranking of world No.

Her career-high ranking in doubles is 153, reached in October 2008.

Thyssen made her WTA Tour main-draw debut at the 2008 Rosmalen Open, in the doubles event partnering Arantxa Rus.