However, in Rome, he also gained favor from the Roman Senate, forcing Prusias to send an emissary named Menas with secret orders to assassinate him.

[1] But the emissary revealed the plot, and persuaded the prince to rebel against his father.

[2] Supported by Attalus II Philadelphus, king of Pergamon, he was completely successful, and ordered his father to be put to death at Nicomedia.

[3] During his long reign Nicomedes adhered steadily to the Roman alliance, and assisted them against the pretender to the throne of Pergamon Eumenes III.

Nicomedes introduced the Bithynian era for numbering years on his coins.