[2][5] It is the most common ornamental Nicotiana variety found and sold in the United Kingdom.

Nicotiana × sanderi requires soft soil mixed with sand to thrive.

[citation needed] Nicotiana × sanderi is not hardy against frost and will die if it comes in contact with it; however, it withstands drought.

Because of its size, N. × sanderi is used as a house or garden plant.

An analytical study published in 1963 concluded that N. × sanderi leaves have a low nicotine concentration and a moderately low nornicotine concentration.